Welcome to KOFFI-DB

KOFFI-DB (???) is an article based database for kinetic constants of biomolecular interactions. We focused on interactions between DNA, RNA, proteins and chemical compounds. All datapoints were manually annotated and reviewed based on open source articles available on Europe PMC.

You can search for interactions using our main or advanced search. Detailed informations can be obtained by clicking on individual interaction. It is also possible to incorporate KOFFI-DB in your program by making use of our REST-API. Find more information in our Document section.

We also implemented KOFFI-DB in Anabel - A free and open source software for the analysis of biomolecular binding events. Here, analysed data can be directly compared with the literature data from KOFFI-DB.


Currently, our database features 1705 individual entries.

Additional Resources

Download KOFFI-DB

Click here to download a csv file containing all binding interactions


Annotation Form:

Click here to download our blank annotation form.

Cite us:

To be published...


Stefan Krämer:


Leo Norval

Dr. Günter Roth